15 de Novembro, 2009
Estudo de coorte coreano abrangendo quase meio milhão de indivíduos associa menor mortalidade total a colesterol total no intervalo 211-251 mg/dl, onde é que também já ouvimos falar disto antes?
É curioso como o gráfico das várias mortalidades, em função do colesterol total, obtidos neste extenso estudo observacional, incidindo sobre 482.472 homens coreanos, resulta tão parecido com o gráfico que também eu produzi no meu artigo Lowest mortality observed when total cholesterol (t-C) is 200-240 mg/dl. O gráfico coreano é o apresentado abaixo, e o meu gráfico pode ser visualizado aqui. Utilizando bases de dados completamente distintas, a conclusão dos coreanos é que a menor mortalidade está associada ao intervalo de t-C 211-251 mg/dl, ou seja, praticamente o mesmo que eu obtive. Como diriam naquele anúncio, há coisas fantásticas, não há?
Am J Epidemiol. 2000 Apr 15;151(8):739-47.
Department of Family Medicine, SungKyunKwan University School of Medicine, Suwon, Korea.
Comment in: Am J Epidemiol. 2000 Apr 15;151(8):748-51.
To evaluate the relation between low cholesterol level and mortality, the authors followed 482,472 Korean men aged 30-65 years from 1990 to 1996 after a baseline health examination. The mean cholesterol level of the men was 189.1 mg/100 ml at the baseline measurement. There were 7,894 deaths during the follow-up period. A low cholesterol level (<165 mg/100 ml) was associated with increased risk of total mortality, even after eliminating deaths that occurred in the first 5 years of follow-up. The risk of death from coronary heart disease increased significantly in men with the highest cholesterol level (> or =252 mg/100 ml). There were various relations between cholesterol level and cancer mortality by site. Mortality from liver and colon cancer was significantly associated with a very low cholesterol level (<135 mg/100 ml) without any evidence of a preclinical cholesterol-lowering effect. With lengthening follow-up, the significant relation between a very low cholesterol level (<135 mg/100 ml) and mortality from stomach and esophageal cancer disappeared. The cholesterol level related with the lowest mortality ranged from 211 to 251 mg/100 ml, which was higher than the mean cholesterol level of study subjects.
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