Canibais e Reis

No estudo de revisão abaixo citado, pode ler-se o seguinte: "Each trial randomised participants to the intervention or control conditions with equal probability. Cholesterol reduction in the intervention groups was accomplished in two trials (table I) by dietary interventions aimed at reducing consumption of cholesterol and saturated fat and in the four other trials by pharmacological treatment, with each using a different drug". Portanto, a dieta low-fat preferida das autoridades de saúde, para baixar o colesterol total, o que de facto acontece. Dieta sempre pobre em gorduras, em especial saturadas, e necessariamente rica em hidratos de carbono. Algumas das intervenções também utilizaram estatinas. Resultado final? Veja a página 311, tabelas 2 e 3 e retire as suas próprias conclusões acerca da "colossal" eficácia que é a redução do colesterol e das gorduras da dieta, do uso de estatinas, etc. nas várias possibilidades de mortalidade. E eu já nem digo mais nada…

Lowering cholesterol concentrations and mortality: a quantitative review of primary prevention trials. (pdf)

Muldoon MF, Manuck SB, Matthews KA.

Department of Medicine, University of Pittsburgh, PA 15260.

OBJECTIVE–To determine the effects of lowering cholesterol concentrations on total and cause specific mortality in randomised primary prevention trials. DESIGN–Qualitative (meta-analytic) evaluation of total mortality from coronary heart disease, cancer, and causes not related to illness in six primary prevention trials of cholesterol reduction (mean duration of treatment 4.8 years). PATIENTS–24,847 Male participants; mean age 47.5 years. MAIN OUTCOME MEASURES–Total and cause specific mortalities. RESULTS–Follow up periods totalled 119,000 person years, during which 1147 deaths occurred. Mortality from coronary heart disease tended to be lower in men receiving interventions to reduce cholesterol concentrations compared with mortality in control subjects (p = 0.06), although total mortality was not affected by treatment. No consistent relation was found between reduction of cholesterol concentrations and mortality from cancer, but there was a significant increase in deaths not related to illness (deaths from accidents, suicide, or violence) in groups receiving treatment to lower cholesterol concentrations relative to controls (p = 0.004). When drug trials were analysed separately the treatment was found to reduce mortality from coronary heart disease significantly (p = 0.04). CONCLUSIONS–The association between reduction of cholesterol concentrations and deaths not related to illness warrants further investigation. Additionally, the failure of cholesterol lowering to affect overall survival justifies a more cautious appraisal of the probable benefits of reducing cholesterol concentrations in the general population.